Mihir Chavda will be delivering an oral presentation on our group’s latest methodology and natural product synthesis at the upcoming ACS Fall 2026 National Meeting in Chicago.

• Speaker: Mihir Chavda
• Presentation Title: Iodine(III)-Mediated Intramolecular Oxamidation of Unsaturated O-Alkyl Hydroxamates: Application to the Tricyclic Core and Macrocyclic Ring A of Zamamiphidin A
• Division: Division of Organic Chemistry (ORGN)
• Session: Total Synthesis of Complex Molecules (8:00 AM – 12:00 PM CDT)
• Format: In-Person Oral Presentation
• Date & Time: Thursday, August 27, 2026 | 11:20 AM – 11:40 AM CDT
• Location: Room W180, McCormick Place Convention Center

The work applies the group’s iodine(III)-mediated oxamidation chemistry — previously used to reach the morphan core of madangamine D — to zamamiphidin A, one of several alkaloid targets built around the cage-like 2-azabicyclo[3.3.1]nonane ring system.



Congratulations to Mihir on the upcoming talk! If you will be attending ACS Fall 2026, make sure to stop by Room W180 on Thursday morning to hear about the project.

Congratulations to Sruthi Mohan, Sebastian Marquez, Mario Noboa and Tim Ponsot, whose work appears in the Journal of Medicinal Chemistry: “Macrophage-Centric Phenotypic Screening Identifies Tetrazolone-Based HDAC6 Inhibitors That Reprogram the Tumor Immune Microenvironment and Improve Immune Checkpoint Blockade,” J. Med. Chem. 2026, 69(11), 12870–12897. DOI: 10.1021/acs.jmedchem.5c02453

This paper is the product of years of sustained effort, and reflects real dedication from everyone involved. It spans two generations of the group: Mario and Tim are graduate students here now, while Sruthi and Sebastian have since completed their doctorates and now work at Argonne National Laboratory and AbbVie, Inc., respectively. The study was carried out in collaboration with the research groups of Alejandro Villagra at Georgetown University and Cyril Bařinka at the Institute of Biotechnology of the Czech Academy of Sciences.