July 2026
Mihir Chavda to speak on zamamiphidin A at ACS Fall 2026
July 30, 2026
Mihir Chavda will give a talk at ACS Fall 2026, which runs from August 23 to 27 at McCormick Place in Chicago. He speaks on Thursday, August 27 at 11:20 AM in room W180, in the Division of Organic Chemistry’s session on Total Synthesis of Complex Molecules.
The talk is titled “Iodine(III)-mediated intramolecular oxamidation of unsaturated O-alkyl hydroxamates: Application to the tricyclic core and macrocyclic ring A of zamamiphidin A.”
It applies the group’s oxamidation chemistry — the iodine(III)-mediated cyclization of unsaturated O-alkyl hydroxamates, already used to reach the morphan core of madangamine D — to zamamiphidin A, one of the current targets in the total synthesis program. Like the other alkaloids in that group, it is built around the cage-like 2-azabicyclo[3.3.1]nonane ring system.
The talk is titled “Iodine(III)-mediated intramolecular oxamidation of unsaturated O-alkyl hydroxamates: Application to the tricyclic core and macrocyclic ring A of zamamiphidin A.”
It applies the group’s oxamidation chemistry — the iodine(III)-mediated cyclization of unsaturated O-alkyl hydroxamates, already used to reach the morphan core of madangamine D — to zamamiphidin A, one of the current targets in the total synthesis program. Like the other alkaloids in that group, it is built around the cage-like 2-azabicyclo[3.3.1]nonane ring system.
Tetrazolone-based HDAC6 inhibitors published in J. Med. Chem.
July 29, 2026
Congratulations to Sruthi Mohan, Sebastian Marquez, Mario Noboa and Tim Ponsot, whose work appears in the Journal of Medicinal Chemistry: “Macrophage-Centric Phenotypic Screening Identifies Tetrazolone-Based HDAC6 Inhibitors That Reprogram the Tumor Immune Microenvironment and Improve Immune Checkpoint Blockade,” J. Med. Chem. 2026, 69(11), 12870–12897. DOI: 10.1021/acs.jmedchem.5c02453
This paper is the product of years of sustained effort, and reflects real dedication from everyone involved. It spans two generations of the group: Mario and Tim are graduate students here now, while Sruthi and Sebastian have since completed their doctorates and now work at Argonne National Laboratory and AbbVie, Inc., respectively. The study was carried out in collaboration with the research groups of Alejandro Villagra at Georgetown University and Cyril Bařinka at the Institute of Biotechnology of the Czech Academy of Sciences.
This paper is the product of years of sustained effort, and reflects real dedication from everyone involved. It spans two generations of the group: Mario and Tim are graduate students here now, while Sruthi and Sebastian have since completed their doctorates and now work at Argonne National Laboratory and AbbVie, Inc., respectively. The study was carried out in collaboration with the research groups of Alejandro Villagra at Georgetown University and Cyril Bařinka at the Institute of Biotechnology of the Czech Academy of Sciences.