Tetrazolone-based HDAC6 inhibitors published in J. Med. Chem.
July 29, 2026
Congratulations to Sruthi Mohan, Sebastian Marquez, Mario Noboa and Tim Ponsot, whose work appears in the Journal of Medicinal Chemistry: “Macrophage-Centric Phenotypic Screening Identifies Tetrazolone-Based HDAC6 Inhibitors That Reprogram the Tumor Immune Microenvironment and Improve Immune Checkpoint Blockade,” J. Med. Chem. 2026, 69(11), 12870–12897. DOI: 10.1021/acs.jmedchem.5c02453
This paper is the product of years of sustained effort, and reflects real dedication from everyone involved. It spans two generations of the group: Mario and Tim are graduate students here now, while Sruthi and Sebastian have since completed their doctorates and now work at Argonne National Laboratory and AbbVie, Inc., respectively. The study was carried out in collaboration with the research groups of Alejandro Villagra at Georgetown University and Cyril Bařinka at the Institute of Biotechnology of the Czech Academy of Sciences.
This paper is the product of years of sustained effort, and reflects real dedication from everyone involved. It spans two generations of the group: Mario and Tim are graduate students here now, while Sruthi and Sebastian have since completed their doctorates and now work at Argonne National Laboratory and AbbVie, Inc., respectively. The study was carried out in collaboration with the research groups of Alejandro Villagra at Georgetown University and Cyril Bařinka at the Institute of Biotechnology of the Czech Academy of Sciences.