Mihir Chavda to Present Group Research at ACS Fall 2026

August 21, 2026

Mihir Chavda will be delivering an oral presentation on our group’s latest methodology and natural product synthesis at the upcoming ACS Fall 2026 National Meeting in Chicago.

Speaker: Mihir Chavda
Presentation Title: Iodine(III)-Mediated Intramolecular Oxamidation of Unsaturated O-Alkyl Hydroxamates: Application to the Tricyclic Core and Macrocyclic Ring A of Zamamiphidin A
Division: Division of Organic Chemistry (ORGN)
Session: Total Synthesis of Complex Molecules (8:00 AM – 12:00 PM CDT)
Format: In-Person Oral Presentation
Date & Time: Thursday, August 27, 2026 | 11:20 AM – 11:40 AM CDT
Location: Room W180, McCormick Place Convention Center

The work applies the group’s iodine(III)-mediated oxamidation chemistry — previously used to reach the morphan core of madangamine D — to zamamiphidin A, one of several alkaloid targets built around the cage-like 2-azabicyclo[3.3.1]nonane ring system.

Reaction scheme for the synthetic route to zamamiphidin A: an unsaturated O-methyl hydroxamate (a cyclohexene bearing a pendant butenyl chain and a CH2C(=O)NHOMe group) is converted in two steps into a tricyclic amino alcohol that contains a macrocyclic ring and the cage-like 2-azabicyclo[3.3.1]nonane core. At right, the full structure of zamamiphidin A is shown in a dashed box, with the corresponding substructure highlighted in red.

Congratulations to Mihir on the upcoming talk! If you will be attending ACS Fall 2026, make sure to stop by Room W180 on Thursday morning to hear about the project.