Wardrop Lab Publications

Publications

Macrophage-Centric Phenotypic Screening Identifies Tetrazolone-Based HDAC6 Inhibitors That Reprogram the Tumor Immune Microenvironment and Improve Immune Checkpoint Blockade
Gajendran, N.; Suresh, M.; Marquez R., S. J.; Mohan, S.; Ponsot, T.; Quiceno-Torres, D.; Noboa, M. A.; Weselman, B. T.; Li, X.; Durr, M.; Novakova, Z.; Schutkowski, M.; Hepp, M.; Noonepalle, S.; Barinka, C.; Wardrop, D. J.; Villagra, A.
J. Med. Chem., 2026, 69(11), 12870–12897
DOI: 10.1021/acs.jmedchem.5c02453
Inhibition of Influenza Entry by Organosilicon Compounds
Antanasijevic, A.; Hafeman, N. J.; Shimon, A.; Tundup, S.; Anirudhan, V.; Rong, L.; Manicassamy, B.; Wardrop, D.; Caffrey, M.
J. Med. Virol., 2025, 97(6), e70436
DOI: 10.1002/jmv.70436
Abstract 2253: HDAC6 Inhibitors Reprogram Macrophages in Antitumor-Adoptive Cell Therapy
Reddy Noonepalle, S. K.; Hernandez, M. G.; Aghdam, N.; Gajendran, N.; Suresh, M.; Li, X.; Sehgal, A.; Quiceno, D.; Berrigen, M.; Knox, T.; Tan, K.; Sotomayor, E.; Chiappinelli, K.; Wardrop, D.; Horvath, A.; Dritschilo, A.; Fernandes, R.; Musunuri, K.; Villagra, A.
Cancer Res., 2025, 85(8_Supplement_1), 2253–2253
DOI: 10.1158/1538-7445.am2025-2253
Cell Therapy Using Ex Vivo Reprogrammed Macrophages Enhances Antitumor Immune Responses in Melanoma
Noonepalle, S. K. R.; Gracia-Hernandez, M.; Aghdam, N.; Berrigan, M.; Coulibaly, H.; Li, X.; Zevallos-Delgado, C.; Pletcher, A.; Weselman, B.; Palmer, E.; Knox, T.; Sotomayor, E.; Chiappinelli, K. B.; Wardrop, D.; Horvath, A.; Shook, B. A.; Lee, N.; Dritschilo, A.; Fernandes, R.; Musunuri, K.; Shibata, M.; Villagra, A.
J. Exp. Clin. Cancer Res., 2024, 43(1), 263
DOI: 10.1186/s13046-024-03182-w
Reprogramming Tumor Microenvironment with Intratumor Macrophage Adoptive Cell Therapy in Melanoma
Noonepalle, S. K. R.; Gajendran, N.; Suresh, M.; Li, X.; Hernandez, M. D.; Delgado, C. Z.; Aghdam, N.; Berrigen, M.; Knox, T.; Tan, K.; Durr, M.; Sotomayor, E.; Chiappinelli, K. B.; Wardrop, D.; Horvath, A.; Shook, B. A.; Lee, N. H.; Dritschilo, A.; Fernandes, R.; Musunuri, K.; Shibata, M.; Villagra, A.
Cancer Res., 2024, 84(6_Supplement), 5247–5247
DOI: 10.1158/1538-7445.am2024-5247
N-Morpholinomethyl-5-lithiotetrazole: A Reagent for the One-Pot Synthesis of 5-(1-Hydroxyalkyl) tetrazoles
Panagiotis D. Alexakos and Duncan J. Wardrop
J. Org. Chem., 2019, 84, 12430-12436
DOI: 10.1021/acs.joc.9b01885.
[Supporting Information]
2-Arylidene Hydrazinecarbodithioates as Potent, Selective Inhibitors of Cystathionine γ-Lyase (CSE)
Abir Bhattacharjee, Antara Sinha, Kiira Ratia, Liang Yin, Loruhama Delgado-Rivera, Pavel A Petukhov
Gregory R. J. Thatcher, and Duncan J. Wardrop
ACS Med. Chem. Lett., 2017, 8, 1241–1245
DOI: 10.1021/acsmedchemlett.7b00313
[Supporting Information]
Oxamidation of Unsaturated O-Alkyl Hydroxamates: Synthesis of the Madangamine Diazatricylic (ABC Rings) Skeleton
Abir Bhattacharjee, Mikhail V. Gerasimov, Sam DeJong, and Duncan J. Wardrop
Org. Lett., 2017, 19, 6570–6573
DOI: 10.1021/acs.orglett.7b03283
[Supporting Information]
Stabilization and Improvement of a Promising Influenza Antiviral: Making a PAIN PAINless
Aleksandar Antanasijevic, Nicholas J. Hafeman, Smanla Tundup, Carolyn Kingsley,
Rama K. Mishra, Lijun Rong, Balaji Manicassamy, Duncan Wardrop, and Michael Caffrey
ACS Infect. Dis., 2016, 2, 608–615
DOI: 10.1021/acsinfecdis.6b00046
Synthetic Applications of Nitrenium Ions
Duncan J. Wardrop and Edward G. Bowen
Nitrenes and Nitrenium Ions (eds D. E. Falvey and A. D. Gudmundsdottir),
John Wiley & Sons, Inc., Hoboken, NJ, USA, 2013
DOI: 10.1002/9781118560907.ch10
Inhibition of Influenza H7 Hemagglutinin-Mediated Entry
Aleksandar Antanasijevic, Han Cheng, Duncan J. Wardrop, Lijun Rong, and Michael Caffrey
PLoS ONE, 2013, 8(10), e76363
DOI: 10.1371/journal.pone.0076363
Iodine(III)-Mediated Cyclization of Unsaturated O-Alkyl Hydroxamates: Silyl-Assisted Access to α-Vinyl and α-(2-Silylvinyl) Lactams
Duncan J. Wardrop, Maria Yermolina, and Edward G. Bowen
Synthesis, 2012, 44, 1199-1207
DOI: 10.1055/s-0031-1290750
[Supporting Information]
Dehydrative Fragmentation of 5-Hydroxyalkyl-1H-tetrazoles: A Mild Route to Alkylidenecarbenes
Duncan J. Wardrop and John P. Komenda
Org. Lett., 2012, 14, 1548-1551
DOI: 10.1021/ol300276p
[Supporting Information]
Methods for Direct Alkene Diamination, New & Old
Sam de Jong, Daniel G. Nosal and, Duncan J. Wardrop
Tetrahedron, 2012, 68, 4067-4105
DOI: 10.1016/j.tet.2012.03.036
Discovery, Synthesis, and Biological Evaluation of a Novel Group of Selective Inhibitors of Filoviral Entry
Maria V. Yermolina, Jizhen Wang, Michael Caffrey, Lijun L. Rong, and Duncan J. Wardrop
J. Med. Chem., 2011, 54, 765–781
DOI: 10.1021/jm1008715
Nitrenium Ion-Mediated Alkene Bis-Cyclofunctionalization: Total Synthesis of (−)-Swainsonine
Duncan J. Wardrop and Edward G. Bowen
Org. Lett., 2011, 13, 2376-2379
DOI: 10.1021/ol2006117
[Supporting Information]
Synthesis and Biological Activity of Naturally Occurring α-Glucosidase Inhibitors
Duncan J. Wardrop and Samanthi L. Waidyarachchia
Nat. Prod. Rep., 2010, 27, 1431-1468
DOI: 10.1039/B914958A
Diastereoselective Nitrenium Ion-mediated Cyclofunctionalization: Total Synthesis of (+)-Castanospermine
Duncan J. Wardrop and Edward G. Bowen
Org. Lett., 2010, 12, 5330-5333
DOI: 10.1021/ol102371x
[Supporting Information]
Intramolecular Oxamidation of Unsaturated O-Alkyl Hydroxamates: A Remarkably Versatile Entry to Hydroxy Lactams
Duncan J. Wardrop, Edward G. Bowen, Raymond E. Forslund, Adam D. Sussman and Samanthi L. Weerasekera
J. Am. Chem. Soc., 2010, 132, 1188–1189
DOI: 10.1021/ja9069997
[Supporting Information]
Total Synthesis of the α-Glucosidase Inhibitors Schulzeine A, B, and C and a Structural Revision of Schulzeine A
Duncan J. Wardrop and Edward G. Bowen
J. Am. Chem. Soc., 2009, 131, 6062–6063
DOI: 10.1021/ja9005755
[Supporting Information]
Total Synthesis of (±)-Agelastatin A, A Potent Inhibitor of Osteopontin-Mediated Neoplastic Transformations
David P. Dickson and Duncan J. Wardrop
Org. Lett., 2009, 11, 1341-1344
DOI: 10.1021/ol900133v
[Supporting Information]
Reduction of Solid-Supported Olefins and Alkynes
David P. Dickson, Christine Toh, Menaka Lunda, Maria V. Yermolina, Duncan J. Wardrop and Chad L. Landrie
J. Org. Chem., 2009, 74, 9535–9538
DOI: 10.1021/jo901764u
[Supporting Information]
Total Synthesis of (±)-Magnofargesin
Duncan J. Wardrop and Joseph Fritz
Org. Lett., 2006, 8, 3659-3662
DOI: 10.1021/ol0609053
[Supporting Information]
Quinocarmycin Analog DX-52-1 Inhibits Cell Migration and Targets Radixin, Disrupting Interactions of Radixin with Actin and CD44
Alem W. Kahsai, Shoutian Zhu, Duncan J. Wardrop, William S. Lane, and Gabriel Fenteany
Chem. Biol., 2006, 13, 973–983
DOI: 10.1016/j.chembiol.2006.07.011
Nitrenium Ion Azaspirocyclization–Spirodienone Cleavage: A New Synthetic Strategy for the Stereocontrolled Preparation of Highly Substituted Lactams and N-Hydroxy Lactams
Duncan J. Wardrop and Matthew S. Burge
J. Org. Chem., 2005, 70, 10271–10284
DOI: 10.1021/jo051252r
Total Synthesis of Polycavernoside A, a Lethal Toxin of the Red Alga Polycavernosa tsudai*
Paul R. Blakemore, Cindy C. Browder, Jian Hong, Christopher M. Lincoln, Pavel A. Nagornyy, Lonnie A. Robarge, Duncan J. Wardrop, and James D. White
J. Org. Chem., 2005, 70, 5449–5460
DOI: 10.1021/jo0503862
Total Synthesis of (−)-Dysibetaine via a Nitrenium Ion Cyclization–Dienone Cleavage Strategy
Duncan J. Wardrop and Matthew S. Burge
Chem. Commun., 2004, 1230–1231
DOI: 10.1039/b403081h
Total Synthesis of the Coccinellid Alkaloid (±)-Adalinine Utilizing a Nitrenium Ion Cyclization
Duncan J. Wardrop, Chad L. Landrie, and José A. Ortíz
Synlett, 2003, 1352
DOI: 10.1055/s-2003-40322
Template-Directed C–H Activation: Development and Application to the Total Synthesis of 7-Episordidin
Duncan J. Wardrop, Raymond E. Forslund, Chad L. Landrie, Adriana I. Velter, Donald Wink, and Bushan Surve
Tetrahedron: Asymmetry, 2003, 14, 929–940
DOI: 10.1016/s0957-4166(03)00091-0
π-Face Selective Azaspirocyclization of ω-(Methoxyphenyl)-N-methoxyalkylamides
Duncan J. Wardrop, Matthew S. Burge, Wenming Zhang, and José A. Ortíz
Tetrahedron Lett., 2003, 44, 2587–2591
DOI: 10.1016/s0040-4039(03)00227-2
Alkylidenecarbene Insertion at Anomeric C–H Bonds. Synthesis of 3-Deoxy-D-arabino-2-heptulosonic Acid (DAH) and 3-Deoxy-D-manno-2-octulosonic Acid (KDO)
Duncan J. Wardrop and Wenming Zhang
Tetrahedron Lett., 2002, 43, 5389–5391
DOI: 10.1016/s0040-4039(02)01078-x
Total Synthesis of the Marine Toxin Polycavernoside A via Selective Macrolactonization of a Trihydroxy Carboxylic Acid*
James D. White, Paul R. Blakemore, Cindy C. Browder, Jian Hong, Christopher M. Lincoln, Pavel A. Nagornyy, Lonnie A. Robarge, and Duncan J. Wardrop
J. Am. Chem. Soc., 2001, 123, 8593–8595
DOI: 10.1021/ja011256n
N-Methoxy-N-acylnitrenium Ions: Application to the Formal Synthesis of (±)-Desmethylamino FR901483
Duncan J. Wardrop and Wenming Zhang
Org. Lett., 2001, 3, 2353–2356
DOI: 10.1021/ol0161514
N-Methoxy-N-acylnitrenium Ions: Application to the Formal Synthesis of (−)-TAN1251A
Duncan J. Wardrop and Arindrajit Basak
Org. Lett., 2001, 3, 1053–1056
DOI: 10.1021/ol015626o
Synthesis of Epiantillatoxin, a Stereoisomer of the Potent Ichthyotoxin from Lyngbya majuscula*
James D. White, Roger Hanselmann, and Duncan J. Wardrop
J. Am. Chem. Soc., 1999, 121, 1106–1107
DOI: 10.1021/ja983334l
*These works were undertaken during postdoctoral research in the laboratory of Professor James D. White, Oregon State University.